Another tough loss Wednesday for British Prime Minister Theresa May, as her second attempt to push the Brexit deal through was rejected.
The ministers voted in favour of no deal with 321 to 278 votes.
The UK is set to leave the European Union on March 29, but the two-week deadline may be further away than anticipated.
Ministers are scheduled to vote Thursday on whether to ask the EU for an extension on the Brexit deadline.
May is to make a third attempt to get her deal through, sometime next week.